Activated β2Integrins Restrict Neutrophil Recruitment during Murine Acute Pseudomonal Pneumonia

Neutrophil recruitment to the lungs during bacterial pneumonia.

Intracellular signalling during neutrophil recruitment

Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of the inflammation process and plays a major role in the development of various diseases including several cardiovascular diseases. Neutrophils themselves play a very active role in that process by sensing their environment and responding to the extracellular cues by adhesion and de-adhesion, cellular s...

Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells.

The roles of CXC chemokine-mediated host responses were examined with an A/J mouse model of Legionella pneumophila pneumonia. After intratracheal inoculation of 10(6) CFU of L. pneumophila, the bacterial numbers in the lungs increased 10-fold by day 2; this increase was accompanied by the massive accumulation of neutrophils. Reverse transcription-PCR data demonstrated the up-regulation of CXC c...

Recurrent pseudomonal pneumonia in a young immunocompetent adult - something fishy?

Community-acquired pneumonia due to Pseudomonas aeruginosa typically occurs in patients with pre-existing lung disease and immunocompromised individuals. We report the case of a previously healthy young adult who presented with recurrent episodes of pneumonia due to Pseudomonas aeruginosa complicated by pleural effusion. Careful and extensive evaluation ultimately revealed the unusual reason be...

Moxifloxacin modulates inflammation during murine pneumonia

BACKGROUND Moxifloxacin is a synthetic antibacterial agent belonging to the fluoroquinolone family. The antimicrobial activity of quinolones against Gram-positive and Gram-negative bacteria is based on their ability to inhibit topoisomerases. Quinolones are described to have immunomodulatory features in addition to their antimicrobial activities. It was the goal of this study to examine whether...